HPE ProLiant DL380 Gen12 Rack Server

The HPE ProLiant DL380 Gen12 Rack Server is a next-generation 2U system for demanding workloads. Supporting next-gen Intel Xeon processors with DDR5 and PCIe Gen5, it delivers scalable compute, advanced security, and flexible infrastructure for modern data centres.

HPE ProLiant DL380 Gen12 Rack Server

HPE ProLiant DL380 Gen12 Key Platform Specifications

  • Primary Use Case: Enterprise Applications
  • Processor Platform: Xeon Scalable 6th Gen
  • Maximum CPUs Supported: 2
  • Maximum Memory Capacity: 8 TB
  • Memory Slots: 32
  • Maximum GPUs Supported: 3
Starting from: £6540.00 Ex. VAT
SKU DL380-Gen12 Categories , , Brand:
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HPE ProLiant DL380 Gen12 Overview

Modern data centres must support rapidly growing workloads while maintaining infrastructure efficiency, security, and long-term scalability.

Next-Generation Compute for Enterprise Infrastructure

The HPE ProLiant DL380 Gen12 delivers enterprise-class performance in a flexible 2U platform powered by Intel Xeon 6 processors. The system supports high-bandwidth DDR5 memory, PCIe Gen5 expansion, and high-speed NVMe storage to support demanding workloads including virtualisation, analytics, and AI-enabled applications. Support for modern memory, storage, and I/O keeps application, database, and virtualisation workloads responsive as utilisation rises and data movement increases across the platform.

Enhanced Platform Bandwidth for Modern Workloads

High-speed I/O and storage connectivity allow networking, storage, and accelerator hardware to operate at full throughput, enabling the platform to support large-scale data processing and compute-intensive applications. High-density compute and platform bandwidth give infrastructure teams more room to consolidate services, standardise deployments, and avoid creating additional server silos as requirements grow. Organisations that require four-socket scale-up in a Gen12 platform may also consider the HPE ProLiant DL580 Gen12 Mission-Critical Server, for supporting larger consolidation and database estates with more CPU and memory headroom.

Supporting Infrastructure Modernisation with Scalable Compute

Improved processor efficiency and expanded platform bandwidth allow organisations to modernise data centre infrastructure while maintaining efficient rack utilisation and operational simplicity.

Our specialists can design and deploy HPE ProLiant DL380 Gen12 platforms aligned with modern enterprise workloads and long-term infrastructure growth.

HPE ProLiant DL380 Gen12 Key Features​

The HPE ProLiant Compute DL380 Gen12 is a versatile 2U rack server designed for enterprise workloads, delivering a balance of performance, scalability, and security for virtualisation, hybrid cloud, and business-critical applications.

Balanced Performance for Enterprise Workloads

Intel Xeon 6 Processor Support
Supports next-generation Intel Xeon processors for improved compute performance and efficiency.

Flexible Memory Capacity
Supports DDR5 memory for high-speed data processing and application performance.

Scalable Storage Options
Supports SFF, LFF, and EDSFF drive configurations to meet diverse workload requirements.

PCIe Gen5 Expansion
Enables high-speed networking and storage expansion.

Secure and Automated Infrastructure Management

HPE iLO 7 Management
Provides secure remote management and server lifecycle control.

HPE Silicon Root of Trust
Delivers built-in security to protect firmware and system integrity.

HPE Compute Ops Management
Provides cloud-based management and visibility across distributed environments.

Speak to an HPE Compute Specialist

Whether supporting virtualisation, hybrid cloud, or enterprise applications, we help design HPE ProLiant DL380 Gen12 environments for performance, scalability, and security.

HPE ProLiant DL380 Gen12 Technical Specifications

Full specifications for this model are listed below.

Additional information

Product Family

HPE ProLiant
Product Series

DL380
Platform Generation

Deployment

Data Centre
Primary Use Case

Enterprise Applications
Product Tier

Flagship
Chassis Type

Form Factor

CPU Vendor

Processor Platform

CPU Architecture Class

Maximum CPUs Supported

Memory Type

Maximum Memory Capacity

Memory Slots

Maximum Memory Speed (MT/s)

Drive Bay Configuration

Maximum Storage Capacity

NVMe Drive Support

Maximum GPUs Supported

PCI Express Slots

PCIe Generation

Embedded Network Ports

Maximum Network Speed

OCP / Network Expansion

Maximum Power Supply (W)

Power Redundancy

Hot-swappable PSUs
Remote Management

Evaluating whether this is the right fit for your environment?

Our specialists are here to help assess compatibility, compare suitable alternatives, or talk through your configuration needs before committing to a solution.

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HPE ProLiant DL380 Gen12 Deployment Scenarios

 

The HPE ProLiant DL380 Gen12 Rack Server is designed for organisations that need a next-generation 2U dual-socket platform for demanding enterprise and hybrid cloud workloads. It is best suited to environments where higher Intel Xeon 6 core density, broader memory scale, and newer front-end storage options matter more than the earlier Gen11 platform or a more compact 1U server.

Hybrid Cloud Refresh

Hybrid cloud estates often need a stronger server baseline as virtualisation density, application demands, and data movement all increase together. The DL380 Gen12 fits these refresh projects where the goal is to modernise core infrastructure without moving away from a versatile 2U enterprise platform.

Data-Intensive Enterprise Applications

Business platforms with heavier data activity need a server that can combine processor scale with more advanced storage layouts. The DL380 Gen12 works well where 8 SFF, 24 SFF, 8 LFF, 12 LFF, or 12 EDSFF options are used to match application behaviour more closely than a one-layout server design allows.

Dense Virtualisation Modernisation

Virtualisation environments replacing older 2U hosts often need a clearer gain in consolidation headroom rather than a simple like-for-like replacement. The DL380 Gen12 suits those deployments where more compute, memory, and faster front-end media need to come together in the same chassis.

NVMe and EDSFF-Led Infrastructure

Modern services increasingly benefit from faster local storage and denser front-end media choices. The DL380 Gen12 is a strong fit where EDSFF or NVMe-led designs support database, analytics, or infrastructure workloads that need more than conventional drive layouts.

Next-Step Enterprise Standardisation

For organisations standardising on a newer compute generation, the DL380 Gen12 provides a broader long-term platform than an entry or single-socket design. It is well matched to mainstream production estates that want one server family for evolving enterprise workloads.

Planning a DL380 Gen12 Deployment?

Our team can help design and deploy HPE ProLiant DL380 Gen12 infrastructure for hybrid cloud, modern enterprise applications, and next-generation 2U compute environments.

As an official HPE partner, we help enterprises unlock flexible financing options that align IT investment with business goals.

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Not sure where to start?

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